【 論文名 】
Patients' choices regarding ventilatory support affect opioid use in amyotrophic lateral sclerosis.
（ALS患者における人工呼吸器の選択はオピオイドの使用に影響を与えるか）

【 発表雑誌 】
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
2025 Jan 24:1-8.　DOI: 10.1080/21678421.2025.2453463

Taylor & Francis（外部リンク）
https://www.tandfonline.com/doi/full/10.1080/21678421.2025.2453463

Objective：To investigate the impact of different ventilatory support options on opioid use among patients with amyotrophic lateral sclerosis (ALS).

Methods：We retrospectively reviewed 889 consecutive patients with ALS and enrolled 399 eligible patients. All patients were followed until death or tracheostomy. Clinical characteristics of patients and the timing of initial opioid administration were evaluated. Patients were categorized into four subgroups: (1) 160 patients who never used a ventilator, (2) 120 patients who used only noninvasive ventilation (NIV), (3) 61 patients who transitioned from NIV to tracheostomy and invasive ventilation (TIV), and (4) 58 patients who underwent TIV without prior NIV. We compared the prevalence of opioid use across these groups and assessed its relationship with ventilatory support options using multivariate logistic analysis.

Results：A total of 130 patients (32.6%) used opioids. The number of patients who used opioids in each group was as follows: 55 (34.4%) in Group 1, 69 (57.5%) in Group 2, 5 (8.2%) in Group 3, and 1 (1.7%) in Group 4 (p < 0.0001). Multivariate logistic analysis revealed that, compared to Group 1, the use of NIV only was positively associated with opioid use (p = 0.002). In contrast, transitioning from NIV to TIV (Group 3) and using TIV only (Group 4) were negatively associated with opioid use (p = 0.0001 and 0.001, respectively).

Conclusions：The choice of ventilatory support significantly influences opioid use in patients with ALS. Patients who opted against TIV required opioids to relieve distress more commonly than those who chose TIV.

本研究は東京都立神経病院との共同研究により行われました。